see a problem on this page? request an account or login and edit it!
Help us create, collect, and correct the world's largest database of physician and medical information!

Anemia, Fanconi

From Wiki Doctor
Jump to navigation Jump to search

This article is a stub. you can help WikiDr by expanding it.



Definition

A rare, inherited disease that adversely affects all the elements of bone marrow and is associated with malformations of the heart, kidney, and limbs, as well as pigmentary changes of the skin. Fanconi anemia predisposes a person to cancer, particularly to a disturbance of bone marrow growth called myelodysplasia and to acute myeloid leukemia. Patients also tend to develop cancers in areas of the body where cells normally reproduce rapidly, such as the mouth, the esophagus, the intestinal and urinary tracts, and the reproductive organs. Fanconi anemia is most common in Ashkenazi Jews. Mutations in multiple different genes can cause the disease, which is inherited as an autosomal recessive trait.


 

 

Other Medical Definitions