Please consider donating to keep our servers running.
Donate $1.00 in Bitcoin Donate $5.00 in Bitcoin Donate $20.00 in Bitcoin Donate $100.00 in Bitcoin
Help us create, collect, and correct the world's largest database of physician and medical information!
Analysis,
This article is a stub. you can help WikiDr by expanding it.
Definition
Study aimed at establishing linkage between genes. Today linkage analysis serves as a way of gene-hunting and genetic testing.Analysis, linkage: Study aimed at establishing linkage between genes. Today linkage analysis serves as a way of gene-hunting and genetic testing.Linkage is the tendency for genes and other genetic markers to be inherited together because of their location near one another on the same chromosome. A gene is a functional physical unit of heredity that can be passed from parent to child. All genes in humans are pieces of DNA. Most genes contain information for making a specific protein. The term "genetic marker" is broader than a gene. A genetic marker is simply a segment of DNA with an identifiable physical location on a chromosome whose inheritance can be followed. A genetic marker can have a function and thus be a gene. Or a marker can be a section of DNA with no known function. Because DNA segments that lie near each other on a chromosome tend to be inherited together, markers are often used as tools for tracking the inheritance pattern of a gene that has not yet been identified but whose approximate location is known.The statistical estimate of whether two loci are likely to lie near each other on a chromosome and are therefore likely to be inherited together is called a LOD score. A LOD score of 3 or more is generally taken to indicate that the two loci are linked and are close to one another.