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A syndromeAdducted thumbs with mental retardation: A syndromewith the following characteristic features:neurologically: mental retardation and aphasia (lack of speech) limbs: adducted (clasped) thumbs, absent extensor pollicis longus and/or brevis muscles to the thumb, shuffling gait, and leg spasticity growth: small body size skeleton: lumbar lordosis (sway back) The syndrome is inherited as an X-linked trait and so affects mainly boys. Alternative names include MASA syndrome (MASA stands for mental retardation, aphasia, shuffling gait, and adducted thumbs), claspedthumb and mental retardation, congenital clasped thumb with mental retardation, and theGareis-Mason syndrome.